Abstract: This article combines studies of international relations and foreign language education and tries to establish a causal relationship between the “foreign language departments growth” and “relationship between China and target countries”. It concludes that international relations have played roles of positioning, orientation, quantitative and qualitative configuration in building foreign language departments. This article focuses on the impacts of the interaction between China and Portuguese-speaking countries on the construction and development of Portuguese departments in the Chinese mainland and Macao. Based on recent development trends between these countries, the paper proposes a possible diversified education of Portuguese majors. It suggests that Portuguese-speaking majors should be cultivated with economic and trade expertise as well as cultural knowledge of the regions concerned, which can be better achieved by exploring the potentials for cooperation between mainland universities and Macao universities.